2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione

Product ID:

ANW-53225

 CAS 50-35-1
Name:

2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione

Synonyms:

CAS:

50-35-1

MDL:

Formula:

C13H10N2O4

Formula Weight:

258.2295

SMILES:

O=C1CCC(C(=O)N1)N1C(=O)c2c(C1=O)cccc2

EINECS:

Pricing/Pack Size

Pack SizePurityPrice (USD)

2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione Chemical Properties

mp 269-271°C
storage temp. Store at RT
solubility 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.6 mg/mL
Water Solubility <0.1 g/100 mL at 22 ºC
Stability:Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference50-35-1(CAS DataBase Reference)
NIST Chemistry ReferencePhthalimide, n-(2,6-dioxo-3-piperidyl)-(50-35-1)
EPA Substance Registry System1H-Isoindole-1,3( 2H)-dione, 2-(2,6-dioxo-3-piperidinyl)- (50-35-1)

2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione Safety Information

Hazard Codes T
Risk Statements 46-61-21-25-62
Safety Statements 53-22-26-36/37/39-45
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS TI4375000
HazardClass 6.1(b)
PackingGroup III
Hazardous Substances Data50-35-1(Hazardous Substances Data)

2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione Usage and Synthesis

Chemical PropertiesWhite Powder
UsageInhibits FGF-induced angiogenesis. Inhibits replication of human immunodeficiency virus type 1. Teratogenic sedative
General DescriptionNeedles or white powder.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileOrganic amides/imides, such as Thalidomide, react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
Fire HazardFlash point data for Thalidomide are not available; however, Thalidomide is probably combustible.
Biological ActivityTeratogen, sedative-hypnotic with inherent anti-inflammatory properties. A selective inhibitor of tumor necrosis factor α (TNF- α ) synthesis.

2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione Raw Materials and Downstream Products